A hormone-free contraceptive pill has been developed for men. It was stated that the birth test pill developed by US scientists showed 99 percent success in the experiments on guinea pigs. Scientists from the University of Minnesota, USA, announced the results of the mouse experiment of the hormone-free birth test pill they developed for men at the spring meeting of the American Chemical Society (ACS) yesterday. Stating that it is 99 percent effective in mice, scientists stated that they will start a human clinical trial as a result of this year.
In scientific study; It was stated that when given orally to male mice for 4 weeks, the birth control compound that makes up the pill significantly reduced the sperm count, and no observable side effects were observed. It was emphasized that the mice returned to normal 4-6 weeks after they stopped taking the compound.
Scientists first tried to create a contraceptive pill for male use in the 1950s. However, the pill man made by the US pharmaceutical company Sterling Drug temporarily sterilized the mice. In trials on male prisoners, it was seen that the drug had a very low sperm count. Then Sterling stopped the trials of the drug. After that, the work in this area was interrupted for about half a century.
Birth Control Methods for Men
Today, men have two options for protection: condoms or permanent vasectomy (a procedure where surgeons cut or close the tubes that carry sperm). However, the number of contraception methods for men could increase this year, the researchers say.
Among the featured drugs is a gel controlled by couples in the UK and USA. The gel in question contains segesterone acetate, which is a combination of a synthetic version of the male sex hormone testosterone. The results are aimed at effectively eliminating sperm production in the testicles, while restricting men's sperm production without affecting their libido.
Christina Wang, MD, of the Los Angeles Biomedical Research Institute, who led the gel trial in the US, explained that there are three potential routes for male birth testing drugs: pills, gel, and monthly injections.
“People love the idea of the daily pill because it's easy. However, only 1 to 3 percent of the drugs are absorbed while taking the pill. On the contrary, while the gel is absorbed at an average rate of 10 percent, the injection enters the body at almost 100 percent. I believe the gel will be approved by the US Food and Drug Administration (FDA), followed by the injection. "Clinical trials show that the gel is safe, well tolerated, and suppresses sperm egress to very low levels in over 90 percent of volunteers."
Clinical Trials Continue!
The injection and pills, on the other hand, are based on an experimental drug called dimethandrolone undecanoate (DMAU). In gel form, they also combine the activity of the compound testosterone and the female hormone progestin.
Stephanie Page, a professor of medicine at the University of Washington, is conducting early-stage clinical trials of DMAU, both as a daily pill and an injection.
Stating that the injection is designed to last up to six months at a time, Page said, “Our phase one study is showing promising results. One hundred men received injections of varying amounts of DMAU. So far, the injections have been extremely well tolerated.”
Professor Page's team has also finished trials of DMAU pills. “The results of the one-month study are very promising and we are analyzing the data of a three-month study. "We hope that by the end of the year, the pills will be on the market," he said.
Researchers at the Indian Medical Research Council are working on a temporary method of vasectomy, a sperm-stopping injection that can prevent pregnancies for up to 13 years. The technique involves deactivating the ducts that carry sperm from the testicles by injecting a plastic called styrene maleic anhydride into them. This chemical is applied by mixing it with dimethyl sulfoxide, a compound that helps plastic bond with tissue in sperm ducts. The combined chemical then produces an electronic charge that stops the sperm from entering the ducts, preventing pregnancy.
Lead researcher Doctor Radhey Shyam said, “The method has already been tried on more than 300 men, declaring that the contraceptive success rate is 97,3 percent and no side effects have been reported. On the other hand, one third of 800 men who participated in a survey in England last year announced that they can use the birth test pill.
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