Recep Tayyip Erdogan University (RTEU) Faculty of Medicine, Department of Basic Medical Sciences. Instructor With the TÜBİTAK 3501 project led by its member Hatice Sevim Nalkıran, it is being investigated whether the stimulation of the antiviral signaling pathway has an effect on increasing the death of bladder cancer cells and whether it can offer an option that can progress to treatment in bladder cancer as an alternative immunotherapy pathway.
Stating that they investigated the effect of targeting the mitochondrial antiviral signaling pathway in bladder cancer cells on the proliferation and death processes of the cells, with the project titled "Examination of the Antiviral Natural Immune Pathway as a Potential Immunotherapeutic Approach in Bladder Cancer". Instructor Member Sevim Nalkıran said, “The signal pathway activated by the detection of viral RNA triggers the stimulation of the immune system. After generating bladder cancer cells with protein levels that we reduce or increase by genetic modulation, we examine whether there is a change in the proliferation and death rates of cancer cells, and then activating the signaling pathway with synthetic viral RNA.” said.
Dr. Instructor Member Sevim Nalkıran said that the project also aimed to create a tumor model by inoculating the cells developed into experimental animals and to follow up the effects after synthetic viral RNA injection.