According to the results of the study, Anadolu Medical Center Medical Oncology Specialist Prof. Dr. Serdar Turhal said, "When the researchers looked at healthy individuals with a normal body mass index, that is, who were not overweight, they saw that this risk reduction was at the level of 17 percent, and they reported that body mass index, that is, being overweight, would contribute to vitamin D in reducing the risk of cancer.
Anadolu Medical Center Medical Oncology Specialist Professor, who initially conducted in 2018, emphasized that it was shown that vitamin D and Omega 3 did not contribute to the formation of cancer, but it was thought that vitamin D could have a borderline contribution to cancer-related deaths. Dr. Serdar Turhal said, “Now the secondary follow-up analysis of this VITAL study has been done. In this study, the researchers questioned whether there was an association between vitamin D intake and the risk of metastatic or fatal cancer. When their results were published recently, they reported that vitamin D overall reduced the risk of developing advanced cancer by 17 percent. "When the researchers looked at participants with a normal body mass index, that is, who were not overweight, they found that this risk reduction was at the order of 38 percent, and they reported that body mass index, that is, being overweight, would also contribute to vitamin D's reduction in cancer risk.
Its contribution to those who are not overweight is higher
Stating that this treatment is a drug that is cheap, easily accessible and has been used for many years, the researchers said that the contribution of the people who are not overweight should be taken into consideration, Medical Oncology Specialist Prof. Dr. Serdar Turhal said, “This 5-year study was a study in the control arm without any medication, which we call placebo. In this study, men were over 50 years old and women over 55, and they were individuals who had never been diagnosed with cancer. It was a study that questioned the contribution of both vitamin D and Omega-3 supplements. A group of patients were given both Omega-3 and vitamin D, a group of patients only vitamin D, a group of patients only Omega-3, and a group of patients with capsules similar to these drugs, but hollow. Not only cancer, but also heart diseases were questioned in these patients, ”he said.
Decreases metastatic and advanced stage cancer
As a result of the first part of this study in 2018, Medical Oncology Specialist Prof. Dr. Serdar Turhal said, “The secondary analysis questioned whether metastatic or fatal cancer was different in patients who received vitamin D, and also questioned whether the patients' body mass index, ie whether they were overweight, contributed to this course. During this study, in which 25 thousand people were observed, 1617 people were diagnosed with cancer in the following 5 years. Among these cancers, primarily breast cancer, prostate cancer, colon cancer, lung cancer were observed, but there were other rare cancers. Among the participants, 13 of the 226 thousand people who took vitamin D had cancer. Those who took the empty tablets, called placebos, were 274. 7843 of the participants (less than 25 percent) were at their ideal weight. Among these people, 58 people who took vitamin D had cancer. Relationships between vitamin D and body mass index in this study, that is, being overweight, may have been found by chance, because the numbers with cancer are very small. However, doubts are still growing that there may be a relationship between being overweight and the contribution of vitamin D on the course of cancer ”.
Being overweight can reduce the effectiveness of vitamin D
Emphasizing that being overweight causes an inflammation in the body, that is, an inflammatory state, Medical Oncology Specialist Prof. Dr. Serdar Turhal continued his words as follows: “This may reduce the effectiveness of vitamin D both on signal and receptor. Because in the past studies on diabetics, it has been shown that the benefit of vitamin D is higher if patients are not overweight.
Vitamin D deficiency is a common problem in cancer patients, and in one study, approximately 72 percent of patients were vitamin D deficient.
In addition, there are studies showing that being overweight alone increases the risk of cancer.
In the light of this information, we cannot conclude that the administration of vitamin D reduces the occurrence of metastatic cancer, but a doubt has arisen here and I believe that this suspicion should be investigated with further studies. "